Application of FAPI Visualization in the Assessment of Right Ventricular Dysfunction Due to Volume Overload

Launched by BEIJING ANZHEN HOSPITAL · Oct 27, 2024

Keywords

ClinConnect Summary

This is an observational study from Beijing Anzhen Hospital that looks at how the right side of the heart works when there is volume overload from valve problems, especially tricuspid valve insufficiency and right‑sided heart dysfunction. The researchers will use a special imaging test (FAPI nuclear imaging) to look for signs of heart tissue changes or scarring (fibrosis) and see how those findings relate to how well the right heart pumps. The study does not test a drug or device; it’s about understanding heart function better in people with these valve issues.

Who can join and what to expect: Adults aged 18 to 90 who have a clinical diagnosis of tricuspid valve insufficiency and right heart dysfunction may be eligible. You would need to understand the study and sign an informed consent form; people with certain other heart conditions (like major coronary artery disease, some aneurysm-related diseases, or congenital heart disease) would be excluded. Participants may be grouped based on their imaging results (high-FAPI, low-FAPI, or no FAPI findings) and will undergo heart tests at about 15 days and 3 months, including measurements of right‑sided heart function and pressures, plus a test called TAPSE. The study will track several outcomes related to right heart function, and is currently enrolling by invitation with an estimated 90 participants, conducted over a few years and conducted in China.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinical diagnosis of Tricuspid valve insufficiency; must understand the purpose of the study and signed an informed consent form;
• Exclusion Criteria:
• • Combined coronary artery stenosis; Combined with aortic aneurysm related diseases; Patients with congenital heart disease;