The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain

Launched by UNIVERSITY OF AARHUS · Oct 29, 2024

Keywords

ClinConnect Summary

The Lactate Project is a clinical trial that aims to understand how increasing levels of lactate in the blood affect the heart and brain. Researchers believe that when lactate levels rise, it could change how the heart and brain use other energy sources, like glucose. Specifically, they think that higher lactate might reduce the brain's use of glucose while increasing blood flow to the brain. For the heart, they expect that increased lactate will lower the uptake of certain fats and glucose, but improve blood flow to the heart muscle.

This study is looking for participants aged 55 to 75 years, including both men and postmenopausal women, with a body mass index (BMI) between 20 and 35. To participate, individuals must sign a consent form and pass a health screening to ensure they don’t have serious medical issues. Participants can expect to undergo some tests and evaluations related to their heart and brain health during the study. It’s important to note that people with certain health conditions, recent blood donations, or those who smoke or have substance abuse issues cannot participate. If you're interested, keep an eye out for more information as the trial is not yet recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 55-75 years
• • 2. Male or postmenopausal female
• • 3. BMI 20-35 kg/m2
• • 4. Signed informed consent form
• Exclusion Criteria:
• • 1. Clinically significant heart, lung, kidney, kidney, liver, endocrine or malignant disease basedon information obtained during an initial screening visit as well as blood samples and an ECG.
• • 2. Blood donation within the last 3 months
• • 3. Smoking
• • 4. Alcohol- or substance abuse
• • 5. Participation in other clinical trials involving ionized radiation within the last 6 months
• • 6. Claustrophobia