Bone Properties Following Exercise Induced Changes in Insulin Sensitivity in People with Type 2 Diabetes

Launched by AARHUS UNIVERSITY HOSPITAL · Oct 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how moderate exercise, specifically biking, can improve insulin sensitivity in people with type 2 diabetes and how these changes may affect bone health. Researchers want to see if exercising for 12 weeks can help improve the way bones turn over and their overall strength, especially since people with type 2 diabetes often have a higher risk of bone fractures due to changes in bone health.

To join the study, participants need to be at least 45 years old, have type 2 diabetes, and for women, be postmenopausal. Some individuals may not be eligible if they have recently changed their diet or exercise habits, are taking certain medications, or have specific health conditions. Those who qualify will engage in a guided exercise program and have their bone health monitored throughout the trial. This research could provide valuable insights into how exercise might help improve bone health in people living with diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diabetes mellitus type 2
• • Age ≥ 45 years
• • Male or female sex
• • Women must be postmenopausal
• Exclusion Criteria:
• • Recent substantial changes in diet (within 3 months)
• • Recent substantial changes in activity level (within 3 months)
• • Recent substantial weight changes (within 3 months)
• • Current or previous treatment (within the last 2 years) with non-oral anti-diabetics or oral GLP-1 analogs
• • HbA1c ≥ 90 mmol/mol
• • HbA1c \< 48 mmol/mol without anti-diabetic medication
• • Premature menopause (menopause before 40 years of age)
• • Current pregnancy
• * Treatment with one of the following medications:
• • Systemic glucocorticoids (within the last 2 years)
• • Antiresorptive or bone anabolic medication (ever)
• • Lithium (ever)
• • Anticonvulsive medication (current)
• • Menopausal replacement therapy (currently)
• • Estimered glomerular filtrationsrate (eGFR) \< 60 mL/minutes
• • High level of physical activity, assessed by the investigators to interfere with the study results
• • Substantial cardiovascular, endocrine, renal, hepatic, rheumatological, gastrointestinal or other disorders assessed by the investigator
• • Electronic implants
• • Osteoporosis or other bone disease
• • Resent bone fracture (within 6 months)
• • Previous bone fracture in either both tibial bones or both radial bones
• • Parathyroid or calcium metabolism disorder
• • Vitamin D deficiency (\< 50 nmol/L)
• • Other substantial medical disorder in unstable phase or active cancer within the last five years except spino- or basocellular carcinoma
• • Lack of ability to complete the intervention
• • Patients assessed uneligible by the investigator to participate in the study