Clinical Study of G Protein Biased Μ - Opioid Receptor Agonist Oliceridine for Optimizing Postoperative Analgesia Under General Anesthesia

Launched by HENAN PROVINCIAL PEOPLE'S HOSPITAL · Oct 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new medication called oliceridine, which is designed to help manage pain after surgery, specifically for older adults. The research aims to compare how well oliceridine works for pain relief compared to a traditional opioid medication called sufentanil. Opioids can be effective for treating moderate to severe pain, but they also come with risks, such as low blood pressure, breathing problems, and nausea. The goal of this study is to find out if oliceridine can provide effective pain relief with fewer side effects.

To participate in this trial, you need to be over 65 years old, generally healthy (with certain medical criteria), and scheduled for knee joint replacement surgery under general anesthesia. You'll also need to be able to read, write, and sign consent forms. If you join, you can expect to receive pain management through a special pump that allows you to control your pain medication after surgery. It's important to note that some people may not qualify, such as those with chronic pain conditions or certain health issues. This study is currently not recruiting participants yet, but it aims to contribute to better pain management options for older adults in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age\>65 years old
• • 2. ASA Level I-III
• • 3. BMI 18.5-29.9
• • 4. Patients undergoing knee joint surface replacement surgery under general anesthesia
• • 5. Postoperative Patient Controlled Intravenous Analgesia Pump (PCIA) Treatment
• • 6. Possess reading and writing abilities
• • 7. You can sign an informed consent form
• Exclusion Criteria:
• • 1. Suffering from chronic pain or mental illness before surgery
• • 2. Unable to communicate due to cognitive impairment or language barriers before surgery
• • 3. Patients who have used opioid drugs three days before surgery
• • 4. Patients with long-term alcohol consumption
• • 5. Abnormal liver and kidney function or dialysis patients
• • 6. Concurrent severe cardiovascular, respiratory, and autonomic neuropathy
• • 7. Participated in clinical studies of other drugs or medical devices in the past 3 months