NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX as Conversion Therapy of Locally Advanced Pancreatic Cancer

Launched by THE AFFILIATED NANJING DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL · Oct 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment approach for patients with locally advanced pancreatic cancer, which is a challenging stage of the disease. Researchers want to compare two different methods: one that combines a medication called NALIRIFOX with a type of radiation therapy known as PD-1 Sequential Radiotherapy, and the other using NALIRIFOX alone. The goal is to see which method is more effective and safe for helping patients in this situation.

To be eligible for the trial, participants must have a confirmed diagnosis of pancreatic cancer and be in good enough health to participate, meaning they should not have severe symptoms or previous cancer treatments. The trial is open to adults aged 18 and older, and individuals will need to provide written consent to join. Those who are pregnant, have certain autoimmune conditions, or have a history of severe bleeding may not be able to participate. If you or a loved one are considering this trial, you can expect to receive careful monitoring and support throughout the process as researchers gather important information about these treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Histologically or cytologically confi rmed pancreatic cancer;
• • 2. ECOG performance no more than 1;
• • 3. Radiographically assessed as locally advanced pancreatic cancer according ;
• • 4. No previous anti-tumor therapy;
• • 5. Able and willing to provide a written informed consent.
• Exclusion Criteria:
• • 1. Prior anti-tumor therapy of any kind;
• • 2. Known to be symptomatic central nervous system metastasis and/or cancerous meningitis.
• • 3. Patients with autoimmune disease or immune deficiency who are treated with immuno-suppressive drugs;
• • 4. Patients with bleeding tendency;
• • 5. Pregnant or lactating women.