MOVE-HF MOtivating Physical Activity With BehaVioral Economics in Heart Failure With Preserved Ejection Fraction

Launched by UNIVERSITY OF PENNSYLVANIA · Oct 31, 2024

Keywords

ClinConnect Summary

The MOVE-HF trial is studying ways to help people with heart failure who have a preserved ejection fraction (HFpEF) increase their physical activity. The researchers want to see if adding fun elements, like games and social challenges, can motivate participants to move more. The trial will involve a 2-week period where participants will track their physical activity to establish a baseline, followed by a 6-month program where they will try the new motivational strategies, and then a 3-month follow-up to see how well they maintained their activity levels.

To join the study, participants must be adults aged 18 or older who have been hospitalized for heart failure in the past 3 years, have a heart function measure known as ejection fraction of 50% or higher, and own a smartphone or tablet with internet access. They also need to understand English and be able to give their permission to participate. However, those who are extremely active (taking more than 7,500 steps a day) or very inactive (fewer than 1,000 steps a day) will not be included, as the study focuses on individuals who are limited in their activity due to heart failure. Participants can expect to engage in a supportive environment aimed at improving their physical health while having fun!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (age ≥ 18 years) who: 1) have a diagnosis of heart failure with preserved ejection; 2) have an ejection fraction ≥ 50%; 3) meet ONE of the following criteria: any history of hospitalization with a primary diagnosis of heart failure with preserved ejection fraction, BNP \> 75 pg/mL (\> 225 pg/mL in patients with atrial fibrillation), H2FPEF score ≥ 5, OR elevated pulmonary capillary wedge pressure on right heart catheterization (≥ 15 mm Hg at rest or ≥ 25 mm Hg with exercise); 4) own a smartphone or tablet capable of connecting to the internet; 5) are able to read English; 6) are able to provide informed consent
• Exclusion Criteria:
• • Participants will be excluded if they are currently participating in another interventional physical activity study, have medical conditions prohibiting ambulation without assistance (including use of an assistive device other than a cane) or participation in an exercise program, if a 9-month physical activity program is infeasible or unsafe, upcoming cardiovascular procedures (e.g. stent or surgery) or if the patient is at a high level of physical activity (\>7500 steps per day) or very low level of physical activity (\< 1000 steps/day) at baseline. Patients taking \> 7500 steps/day will be excluded based on data showing that increasing step count beyond 7500 steps/day does not improve outcomes in all-comer populations, and to ensure that we are recruiting a population of patients with symptomatic HF. Patients taking \< 1000 steps/day at baseline will be excluded to ensure that we will not enroll very frail patients with a need for more intensive exercise training or physical therapy. To ensure that we are capturing patients who are limited in their exertional capacity by heart failure, we will also exclude patients with end-stage renal disease on dialysis, cirrhosis, cardiac surgery or transcatheter valve replacement within the last year, severe aortic stenosis or severe mitral stenosis.