Immunoinflammatory State Detection and Multimodal Brain Imaging and Electrophysiologic Changes in Schizophrenia

Launched by CENTRAL SOUTH UNIVERSITY · Nov 2, 2024

Keywords

ClinConnect Summary

This clinical trial is studying schizophrenia, a serious mental health condition, to understand how the immune system and inflammation may affect the illness. Researchers believe that changes in the immune system could help identify different types of schizophrenia and might relate to how well patients respond to treatment and their cognitive abilities. The trial is looking to gather information using advanced brain imaging techniques and other assessments to explore this connection further.

To participate in the study, individuals must be between 16 and 50 years old and have a confirmed diagnosis of schizophrenia. They should have had the illness for less than 10 years. However, those with certain other mental health issues, severe physical illnesses, or specific genetic disorders will not be eligible. Participants can expect to undergo various tests and evaluations to help researchers learn more about the links between the immune system and schizophrenia, which could lead to better treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Clinical diagnosis that meets ICD-11 criteria for schizophrenia.
• • 2. Confirmation of the diagnosis of schizophrenia using the SCID-5-RV.
• Exclusion Criteria:
• • 1. Clinical diagnosis or SCID-5-RV assessment confirming neurodevelopmental disorders, bipolar and related disorders, substance use disorders (excluding alcohol and tobacco).
• • 2. Presence of severe or acute physical illnesses, including traumatic brain injury, intracranial space-occupying or infectious diseases, acute cardiovascular diseases, acute respiratory system diseases, acute hematological disorders, autoimmune disease, etc.
• • 3. Presence of clearly defined genetic diseases, including tuberous sclerosis, multiple sclerosis, Kleefstra syndrome, 22q11.2 deletion syndrome, Prader-Willi syndrome, Klinefelter syndrome (47, XXY), etc.