Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Nov 5, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding uncommon lipid disorders, which are conditions that affect the levels of fats, like cholesterol and triglycerides, in the blood. These abnormalities can lead to health issues, including atherosclerosis, which is the buildup of fats in the arteries. The goal of the study is to learn how these conditions change over time and how they respond to different treatments. Researchers also hope to develop better ways to diagnose these disorders, ultimately aiming to improve the health of individuals affected by them.

To participate, you need to be at least 10 years old and either already diagnosed with or suspected of having a rare lipid disorder. This trial is open to anyone, regardless of where they live. If you join, you may have up to 15 visits a year where you will undergo physical exams, blood tests, and possibly an EKG to check your heart's activity. Your involvement could last for up to 20 years, but all visits are optional. This study is currently recruiting participants and aims to gather important information that could lead to better care for individuals with these conditions.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Affected Participants
• • Male and female participants age \>= 10 years.
• • Subjects with confirmed or suspected rare disorder that causes lipid/lipoprotein abnormalities (dyslipidemia) or abnormal documented or referred atherosclerosis patterns.
• • Only affected individuals (not healthy volunteers and for self-referred subjects independent of lipid and lipoprotein marker values.); subjects with laboratory or clinical presentation that in the opinion of the Principal Investigator, would alter the determination of normal
• • parameters for assays and screening tools development.
• • -Ability of the subject or Legally Authorized Representative (LAR) to understand and willingness to sign a written informed consent document.
• • Healthy Volunteers
• • Participants must be healthy, with no known history of lipid disorders or related medical conditions.
• • Participants must not be pregnant.
• EXCLUSION CRITERIA:
• • Patients with disorders that cause common secondary/lipoprotein alterations.
• • Patients with any other findings that, in the opinion of the Principal Investigator, would preclude them from participating in the study.