Total Arch Replacement With Frozen Elephant Trunk Versus Hemiarch Replacement in the Management of Acute Type A Aortic Dissection

Launched by CHINESE UNIVERSITY OF HONG KONG · Nov 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying two different surgical procedures for patients with a serious condition called acute type A aortic dissection (ATAAD), which occurs when there is a tear in the aorta, the main artery that carries blood from the heart. The trial will compare the conventional hemiarch replacement surgery, which is simpler but may not fully address the problem, with a more complex procedure called total arch replacement with a frozen elephant trunk, which aims to repair the tear and improve blood flow more effectively.

To be eligible for this trial, participants must be between 18 and 80 years old and have a specific type of aortic dissection with a tear beyond the ascending aorta. They must also be able to give consent and not have severe health issues that would prevent them from participating. If enrolled, patients will be randomly assigned to one of the two surgical groups, and researchers will track their recovery and outcomes for 30 days after surgery. This study is important because it will be the first of its kind to directly compare these two surgical methods, potentially changing how ATAAD is treated in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient 's age is between 18 and 80 years.
• • 2. Patient is willing and able to give informed consent.
• • 3. Patient has acute type A aortic dissection with entry tear beyond ascending aorta.
• • 4. Patient not in coma/irreversible end organ failure/cardiac massage for resuscitation
• Exclusion Criteria:
• • 1. There is no identifiable entry tear in the aorta
• • 2. The ascending entry tear extends into aortic arch
• • 3. Patient has entry tear only in ascending aorta
• • 4. Patient with Type B aortic dissection
• • 5. Patient has co-morbidity (i.e. active malignancy (progressive, stable or partial remission)) causing expected survival to be less than 2 years.
• • 6. Patient has any other medical, social, or psychological problems, that in the opinion of the investigator, preclude the patient from participating in this study.