Investigating the Diagnostic Performance of High-resolution Specimen PET-CT in Determining Margin Status in Cancer Resection

Launched by UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST · Nov 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique called high-resolution specimen PET-CT, which aims to help surgeons determine whether they have completely removed cancer during surgery. When patients undergo surgery for cancers like prostate or head and neck cancer, it’s important for the surgeon to ensure no cancer cells are left behind. If any cancer is missed, patients may need more treatments later on. The new PET-CT scanner can help by showing where the cancer is in the removed tissue, allowing the surgeon to make more informed decisions during the operation.

To participate in this study, patients must be at least 18 years old and scheduled for specific types of cancer surgery: robotic surgery for prostate cancer or surgery for head and neck cancer involving oral squamous cell carcinoma. Participants will receive a small radioactive tracer before their surgery, which helps highlight the cancer cells in the removed tissue. After the surgery, the tissue will be scanned to see how well this new technique works compared to the traditional method of checking the tissue under a microscope. This trial is important because it could lead to better surgical outcomes and reduce anxiety for patients knowing that their cancer has been completely removed.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• For prostate cancer patients:
• • 1. At least 18 years old at time of consent.
• • 2. Listed for Robotic Radical Prostatectomy.
• For head and neck cancer patients:
• • 1. At least 18 years old at time of consent.
• • 2. Listed for resection of oral squamous cell carcinoma head and neck cancer resection.
• • 3. Specimen able to fit into Xeos Aura specimen container.
• Exclusion Criteria:
• For prostate cancer patients:
• • 1. General or local contra-indications for resectional surgery.
• • 2. Lacks capacity to provide informed consent.
• • 3. Currently participating in another interventional research study that in the judgment of the investigator would negatively affect the participant and/or this study's data integrity.
• For head and neck cancer patients:
• • 1. General or local contra-indications for resectional surgery.
• • 2. Lacks capacity to provide informed consent.
• • 3. Pregnant or breast feeding patient.
• • 4. Currently participating in another interventional research study that in the judgment of the investigator would negatively affect the participant and/or this study's data integrity.