Individual Factors of CBT Underlying Success

Launched by UNIVERSITY OF WASHINGTON · Nov 5, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Individual Factors of CBT Underlying Success," is focused on understanding why some people with social anxiety disorder (SAD) or body dysmorphic disorder (BDD) respond well to cognitive behavioral therapy (CBT), while others do not. Researchers will gather various types of information, including brain scans, cognitive tests, and personal feedback, to find clues about what makes therapy effective for some individuals and less so for others.

To participate, you need to be between the ages of 18 and 45 and have a diagnosis of either SAD or BDD. If you do not have any psychiatric disorders and have low levels of anxiety and depression, you could also be part of the control group. Participants will be asked to provide their consent and will undergo assessments to ensure they meet the study criteria. If you join the trial, you'll be contributing to important research that could help improve treatment for people with these conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Clinical sample (N=110):
• • 1. Men and women, age 18-45
• • 2. Treatment-seeking individuals who meet criteria for a primary DSM-5 diagnosis of primary social anxiety disorder (SAD) or body dysmorphic disorder (BDD) based on the SCID-5-RV
• • 3. Fluent in English and willing to provide informed consent.
• Control sample (N=50):
• • 1. Men and women, age 18-45
• • 2. No current or lifetime history of psychiatric disorders, as assessed using the SCID-5-RV
• • 3. Meet criteria for low levels of anxiety (GAD-7 score of \<8) and depression (PHQ-9 score \<10)
• • 4. Fluent in English and willing to provide informed consent
• Exclusion Criteria:
• All groups:
• • 1. Score \< 80 based on WRAT5 Word Reading Subtest
• • 2. fMRI contraindications (e.g., electronic medical devices such as pacemakers, implanted defibrillators, etc.; metal implants not approved for MRI; pregnancy; claustrophobia)
• • 2. Active suicidal or homicidal ideation, or any features requiring a higher level of care 3. Lifetime history of manic or hypomanic episode, psychotic symptoms, traumatic brain injury, neurological disorder, pervasive developmental disorder, or attention deficit-hyperactivity disorder; active alcohol or substance use disorder in the past 6 months 4. Current use of psychotropic medications, except antidepressants taken at a stable dose for 3 months prior to study baseline 5. Previous CBT non-responder or current CBT