Impact of Intrahepatic Cholestasis of Pregnancy on Neonatal Respiratory Outcomes

Launched by CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY · Nov 7, 2024

Keywords

ClinConnect Summary

Intrahepatic cholestasis of pregnancy is a hepatic complication that predominantly arises during the second or third trimester. It is characterized by serum bile acid levels above 10 micromol/L and persistent pruritus, which resolves after delivery. To date, it has been observed that respiratory distress syndrome occurs more frequently in neonates born to mothers with cholestasis of pregnancy, and a potential new entity, 'acute bile acid-induced pneumonia,' has been proposed, though statistical confirmation is lacking. Therefore, the investigators deem it imperative to conduct a study in th...

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Eligibility criteria

• • CASE
• Inclusion Criteria:
• • mother with recent diagnosis of intrahepatic cholestasis of pregnancy (serum bile acids over 10 micromol/l in the last 7 days before birth), with informed consent given a few hours before giving birth
• • ursodeoxycholic acid, independent of dosage or initiation of treatment
• • neonates born in Clinical Hospital of Obstetrics and Gynecology "Prof.Dr. Panait Sirbu"
• Exclusion Criteria:
• • no informed consent
• • serum bile acids under 10 micromol/l in the last 7 days before birth
• • newborns transferred from other neonatal units
• • CONTROL
• Inclusion Criteria:
• • mother with no history of hepatic disease during or before the current pregnancy, with informed consent given a few hours before giving birth
• • neonates born in Clinical Hospital of Obstetrics and Gynecology "Prof.Dr. Panait Sirbu", of similar gestational age/weight/sex at birth to corresponding neonates in the cholestasis group
• Exclusion Criteria:
• • ursodeoxycholic acid, independent of dosage or initiation of treatment (suspected hepatic disease/elevated transaminases)
• • newborns transferred from other neonatal units, with different gestational age/weight/sex than cases