Fibrinolysis Resistance in Infection and Trauma

Launched by ANDERS ANEMAN · Nov 6, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Fibrinolysis Resistance in Infection and Trauma," is focused on understanding blood clotting problems in critically ill patients, particularly those suffering from severe infections like sepsis or after significant injuries. These conditions can cause harmful blood clots, which may lead to serious complications such as organ failure. The researchers are using a special technology called Viscoelastic Testing (VET) to quickly identify patients at risk of developing these dangerous blood clots. They will also test new medications to help manage blood clotting issues and guide treatments that can save lives.

To participate in this trial, patients must be admitted to the Intensive Care Unit (ICU) with sepsis or traumatic injuries and are expected to survive for at least two days. Specific criteria apply, such as needing support for at least one organ or having respiratory support at the time of admission. Patients currently on certain blood-thinning medications or with very severe conditions may not be eligible. Those involved in the study can expect to undergo testing and receive potential new treatments while being closely monitored by healthcare professionals. This trial aims to improve the understanding and management of blood clotting disorders in critical care settings.

Gender

ALL

Eligibility criteria

• Sepsis/Septic shock Inclusion Criteria:
• • Admission to ICU, needing at least one organ supportand principally for the management of clinically suspected Sepsis or Septic shock according to Spesis-3 criteria (including SARS-COV-2)
• • Expected to remain in ICU and survive beyond the day after tomorrow
• Sepsis Exclusion Criteria:
• • On oral anticoagulant/antiplatelet therapy
• • Not for full, active ICU support
• • Death is deemed inevitable within 24 hrs
• Trauma Inclusion Criteria:
• • Trauma is the principal diagnosis on ICU admission
• • Expected to remain in ICU and survive beyond the day after tomorrow
• • Receiving respiratory support at the time of ICU admission - high-flow nasal prongs, non-invasive or invasive ventilation
• • Already received, or considered at risk of needing a blood product transfusion within 24 hrs of injury
• Trauma Exclusion Criteria:
• • Nursing home resident
• • Unsurvivable head injury
• • Not for full, active ICU support
• • Death is deemed inevitable within 24 hrs