Silver Nitrate Vs. Triamcinolone for Treatment of Hypergranulation Tissue

Launched by FRANCESCO EGRO · Nov 6, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how effective two different treatments—silver nitrate and triamcinolone—are for helping wounds that have hypergranulation tissue, which is extra tissue that forms as a wound heals. The study will take place over four years at UPMC Mercy and will involve patients with traumatic wounds that show this condition. Participants will be randomly assigned to receive either silver nitrate, triamcinolone, or both treatments one after the other. The goal is to find out which treatment works best in reducing or eliminating the hypergranulation tissue.

To be eligible for this trial, participants must be at least 18 years old and have non-infected traumatic wounds with hypergranulation tissue. They will also need to agree to take part in the study. However, people with known allergies to the treatments, those with wounds that don’t show hypergranulation, or those with complex or infected wounds won’t be able to participate. If you join the study, you can expect regular check-ins to monitor how your wound responds to the treatment. This research aims to improve care strategies for patients dealing with similar wound healing issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients must be 18 years or older.
• • Patients must be admitted to the institution with non-infected, traumatic wounds exhibiting hypergranulation tissue.
• • Patients must provide consent to participate in the study.
• • Eligible wounds include superficial or partial-thickness wounds.
• • Wounds will be categorized based on size and depth, with variations controlled for in the statistical analysis.
• Exclusion Criteria:
• • Patients with known allergies or contraindications to silver nitrate or triamcinolone.
• • Patients with wounds that do not exhibit hypergranulation tissue.
• • Patients with wounds not primarily due to traumatic injury (e.g., surgical wounds, pressure ulcers).
• • Full-thickness, infected, or complex wounds will be excluded, as these may require different management strategies.