The Role of Microbiome in Recurrent Obesity Before and After Antibiotic/Placebo Treatment

Launched by WEIZMANN INSTITUTE OF SCIENCE · Nov 6, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring how changes in gut bacteria, known as the microbiome, might help people who struggle with obesity to maintain their weight loss. Many people who lose weight end up regaining it, and this study is looking at whether taking antibiotics after losing weight could help prevent that weight regain. The researchers hope to find out if adjusting the microbiome can be a new way to support long-term weight management.

To be eligible for the study, participants should be between 18 and 65 years old and have a body mass index (BMI) between 28 and 35, which indicates they are overweight. They also need to be comfortable using a smartphone app for the study. However, there are certain health conditions and recent treatments that could prevent someone from participating, such as ongoing cancer treatment or certain chronic diseases. If you join the trial, you can expect to take part in assessments and possibly receive an antibiotic treatment, while contributing to important research that could help others with similar struggles in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 28\<BMI\<35
• • Age - 18-65
• • Capable of working with a smartphone application
• Exclusion Criteria:
• • Consumption of antibiotics/probiotics/oral antifungals 2 months prior to the first day of the experiment.
• • Pregnancy, fertility treatments, breastfeeding women six months prior to enrollment and during the study.
• • Chronic disease, to the discretion of the study team (e.g. AIDS, Cushing syndrome, CKD, acromegaly etc.)
• • Cancer and recent anticancer treatment
• • Psychiatric disorders, to the discretion of the study team.
• • Coagulation disorders
• • IBD (inflammatory bowel diseases)
• • Bariatric surgery.
• • Eating disorders (Anorexia nervosa. Bulimia nervosa. Binge eating disorder, Night eating syndrome).
• • Alcohol or substance abuse
• • Weight loss attempts 6 months prior to the first day of the experiment - using weight loss medication.
• • Drastic changes in nutritional habits six months prior to the first day of the study - to the discretion of the study team.
• • Allergy to penicillin.
• • Life threatening reaction after consumption of cephalosporins.
• • History of CDI
• • Liver disease
• • History of serious unresolved diarrhea in response to antibiotic treatment to the discretion of the study doctor.