Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients

Launched by MATIAS VESTED · Nov 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called ephedrine on the time it takes for another medication, rocuronium, to start working in elderly patients who are 80 years old or older. Rocuronium is often used during surgeries to help relax muscles, and the researchers believe that giving ephedrine before rocuronium may help it work faster. The trial is currently looking for participants who are scheduled for elective surgeries that require general anesthesia and intubation, which means they will need help breathing during the procedure.

To be eligible for this study, participants need to be at least 80 years old and in good health according to specific guidelines. However, individuals with certain health conditions, such as allergies to the medications being studied or those who take specific heart medications, cannot participate. If someone decides to join the study, they can expect to receive either ephedrine or a placebo (a harmless saline solution) before their surgery and will be monitored closely by the medical team throughout the process. Participants will also need to be able to read and understand Danish to give informed consent and follow the study instructions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 80
• • Scheduled for elective operations under general anesthesia with intubation
• • American Society of Anesthesiologists physical status classification (ASA) I to III
• • Informed consent
• • Read and understand Danish
• Exclusion Criteria:
• • Known allergy to rocuronium or ephedrine
• • Neuromuscular disease that may interfere with neuromuscular data
• • Indication for rapid sequence induction
• • Daily use of beta-blocking agents
• • Known cardiac arrythmia (atrial fibrillation, supraventricular or ventricular)