Neoadjuvant Chemotherapy Combined With Toripalimab for TNBC (NEOTORCH-BREAST02)

Launched by FIRST AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY · Nov 7, 2024

Keywords

ClinConnect Summary

The NEOTORCH-BREAST02 clinical trial is studying a new treatment approach for women with triple negative breast cancer (TNBC). This trial combines a type of immunotherapy called Toripalimab with standard chemotherapy before surgery, aiming to see how well this combination works in eradicating the cancer. The main goal is to determine how many participants have no detectable cancer in their tissues after treatment, while also keeping track of any side effects. Researchers will also look at how long patients remain cancer-free and how effective the treatment is overall.

To participate in this trial, women aged 18 to 70 with specific types of TNBC are eligible, provided their tumors are larger than 1 cm and they meet certain health criteria. Participants should be in good health and not have significant heart problems or other serious illnesses. Those who join can expect to receive a combination of chemotherapy and Toripalimab, and they will be closely monitored throughout the treatment and recovery process. It's important for potential participants to discuss this opportunity with their doctors to see if it’s the right choice for them.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Female patients aged 18-70 years old;
• • 2. ECOG score is 0-1 points;
• • 3. Histologically proven tumors \>1cm in diameter (T1c-3; N0-2; M0) invasive breast cancer;
• • 4. All patients had triple negative breast cancer confirmed by histopathology;
• 5. Pathological examination of PD-L1 expression:
• • The Combined Positive Score (CPS) refers to the percentage of PD-L1 positive cells (including tumor cells, lymphocytes, macrophages) in all tumor cells. Our center detected the PD-L1 antibody site as 22C3.
• • 6. The functional level of major organs must meet requirements
• • 7. For female patients who have not yet reached menopause or undergone surgical sterilization: during the treatment period and in the study treatment, the final use effective contraceptive methods for at least 6 months after a single administration.
• • 8. Voluntarily join this study, sign an informed consent form, have good compliance, and are willing to cooperate with follow-up.
• Exclusion Criteria:
• • 1. Stage IV breast cancer.
• • 2. Inflammatory breast cancer.
• • 3. Previously received anti-tumor treatment or radiation therapy for any malignant tumor, excluding those that have been cured Malignant tumors such as cervical carcinoma in situ, basal cell carcinoma, or squamous cell carcinoma.
• • 4. Simultaneously undergoing anti-tumor treatment in other clinical trials, including but not limited to chemotherapy and endocrine therapy. Treatment, biological therapy, bone improvement drug therapy, or immune checkpoint inhibitor therapy, etc.
• • 5. The patient had undergone major surgical procedures unrelated to breast cancer within 4 weeks before the first administration of the study drug, or the patient has not fully recovered from such surgical procedures.
• 6. Serious heart disease or discomfort, including but not limited to the following diseases:
• • 1) Diagnosed history of heart failure or systolic dysfunction (LVEF less than 50%).2) High risk uncontrolled arrhythmias, such as atrial tachycardia, resting heart rate greater than 100bpm, significant ventricular arrhythmias (such as ventricular tachycardia), or higher-level atrioventricular block (i.e. Mobitz II second or third degree atrioventricular block).3) Angina requiring medication for treatment. 4) Heart valve disease with clinical significance. 5) ECG shows transmural myocardial infarction. 6) Poor control of hypertension (systolic blood pressure greater than 180mmHg and/or diastolic blood pressure greater than 180mmHg after drug treatment) 100mmHg).
• • 7. Uncontrolled active infections that require treatment; History of immunodeficiency, including HIV testing positive Sexual, or suffering from other acquired or congenital immunodeficiency diseases, or having a history of organ transplantation.
• • 8. Patients with chronic active hepatitis B or active hepatitis C (excluding hepatitis B virus carriers, stable hepatitis B after drug treatment \[HBV-DNA test negative or\<50IU/ml\] and cured hepatitis C patients \[HCV RNA test negative\]).
• • 9. Have received immunotherapy and experienced adverse immune events such as immune related pneumonia and myocarditis, which have been determined by researchers to potentially affect the safety of the experimental medication.
• • 10. Individuals with a known history of allergies to the components of this medication regimen.
• • 11. Pregnant and lactating female patients, female patients with fertility and positive baseline pregnancy test results, or reproductive age patients who are unwilling to take effective contraceptive measures during the entire trial period and within 6 months after the last study medication.
• • 12. Suffering from serious accompanying diseases or other comorbidities that may interfere with the planned treatment, or any other circumstances that the researcher deems unsuitable for the patient to participate in this study.