Diagnostic Efficacy of CDA Nasal Provocation Test in Patients With IR

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · Nov 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a test called the CDA nasal provocation test, which helps diagnose a condition known as idiopathic rhinitis (IR). Chronic rhinitis is a persistent inflammation of the nasal passages that can cause symptoms like a stuffy or runny nose, sneezing, and itching. For people with IR, these symptoms occur without a clear cause, making it tricky to diagnose. The CDA test checks how sensitive the nasal tissues are to cold, dry air, which can help doctors determine if someone has IR. The goal of the study is to gather more information about how effective this test is for diagnosing IR and potentially create a clearer way for doctors to identify and treat this condition.

To be eligible for this trial, participants must be between 18 and 65 years old and have had rhinitis symptoms for more than two years without any known allergies. They must also be willing to take the CDA test and provide samples for the study. Healthy volunteers who do not have any nasal symptoms and are not allergic are also welcome to participate. The trial is not yet recruiting participants, but once it starts, those who join can expect to undergo the CDA test and contribute to important research that may improve diagnosis and treatment for others with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • IR patients: 1. Aged 18-65 years; 2. The presence of symptoms of rhinitis for more than 2 years, often triggered by non-specific stimuli, serum and nasal secretion allergen specific IgE test negative, nasal endoscopy examination ruled out severe anatomical disease and sinusitis with or without polyps, nasal secretion smear no eosinophils, allergic rhinitis, local allergic rhinitis, eosinophilia non-allergic rhinitis were excluded; 3. IR patients who visited the Department of Otorhinolaryngology, the First Affiliated Hospital of Nanjing Medical University and were willing to undergo CDA nasal provocation test; 4.Ptients who are willing to provide specimens for free to promote the study of the diagnostic efficacy of CDA nasal provocation test for IR.
• • Healthy volunteers: 1. Aged 18-65 years; 2. Did not have any nasal symptoms and tested negative for allergens.
• Exclusion Criteria:
• • 1. Patients received glucocorticoids, immunomodulatory drugs, antihistamines, and other treatments that may affect the study results within the past 1 month. 2. Patients with unstable diseases (including severe asthma) and active immune system diseases; 3. Smoking; 4. Pregnant or lactating women; History of nasal surgery within 5.3 months; 6. Patients with any nasal conditions that may interfere with the efficacy or safety evaluation of CDA nasal provocation test; 7. Patients with low compliance and refusing to accept specimen and questionnaire collection.