The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young Males

Launched by MCGILL UNIVERSITY · Nov 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how taking a specific type of ketone supplement, called a ketone monoester, affects hormone levels in healthy young men after they do resistance exercise, like weightlifting. Hormones such as testosterone and growth hormone play important roles in building muscle, and the researchers want to see if the ketone supplement changes how these hormones respond after working out compared to a placebo drink (just flavored water).

To participate in this study, men between the ages of 18 and 40 who are generally healthy and active can apply. Participants should not have any major health issues, like diabetes or heart problems, and must avoid alcohol for 48 hours before the testing days. If you join, you will consume the ketone drink or the placebo and then engage in a resistance exercise session. The study aims to better understand how these supplements might influence hormone responses after exercise, which could have implications for fitness and muscle growth.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy adult male participants who are 18-40 years of age (inclusive).
• • BMI \>18.5 and \<30.0 kg/m2
• • Recreationally active (at least of 150 minutes of activity/week).
• • Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study.
• • Be willing to entirely avoid alcohol consumption 48 hours prior to the test days.
• • Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures.
• Exclusion Criteria:
• • Individuals with metabolic disorders including: Type I or Type II diabetes.
• • Individuals with a history of thrombosis / cardiovascular disease, endocrine disorders
• • Individuals with knee injuries (i.e., ACL injuries).
• • Individuals with a positive medical history of unstable thyroid disease (i.e., hypothyroidism, hyperthyroidism, hyperparathyroidism, and hypoparathyroidism) and immune disorders.
• • Individuals who have used tobacco products within the last 6 months.
• • Chronic usage of medications known to modulate hormone levels (i.e. corticosteroids and hormone replacement therapy (HRT)) in the last 6 months.
• • Current use of ketone supplements or adherence to a ketogenic diet.
• • Formal or regular weightlifting activity within the last year.