The Validity of Thorathic Fluid Content As Non Invasive Predictor on Weaning of Mechanical Ventilation in Critically Ill Patients

Launched by ZAGAZIG UNIVERSITY · Nov 9, 2024

Keywords

ClinConnect Summary

This study from Zagazig University in Egypt is trying to find out if a noninvasive test that measures thoracic (chest) fluid content can help predict which critically ill adults on a ventilator will have trouble coming off the machine. Researchers will look at thoracic fluid content, daily fluid balance, and certain heart measurements taken before a spontaneous breathing trial to see if these tests can forecast a failed weaning from mechanical ventilation over about six months. It’s a single-group, diagnostic-type study, and the study is currently enrolling about 120 participants. Results have not been published yet.

Who can join: adults 18 years and older who are in the ICU, on mechanical ventilation for more than 48 hours, and have multisystem illness. They must be able to give consent themselves or have a legally authorized representative. Exclusions include significant fluid around the lungs or heart, pneumothorax or severe emphysema, certain heart rhythm problems, injuries or burns at the device sites, or other conditions that would interfere with the measurements. What you or a participant would experience: a brief, noninvasive chest test to measure thoracic fluid content using chest/neck electrodes for about 30 seconds, plus an ultrasound test of the heart to measure specific factors, and review of fluids given in the prior 24 hours. The ICU team will perform a spontaneous breathing trial to decide if the patient can be extubated, and data on outcomes will be collected with the goal of improving future weaning decisions. The study is overseen by a Data Monitoring Committee and is not a drug trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 2. Patients or first degree relative's acceptance. All patients who are mechanically ventilated for more than 48 hours. 3. Gender: both sexes. 4. 5. Age: above 18 years old. Critically ill patients who suffer from multisystem diseases that can result in significant morbidity or mortality.
• Exclusion Criteria:
• • - 1. Patients with significant pleural or pericardial effusion. 2. Presence of pneumothorax or severe subcutaneous emphysema. 3. Patients with significant valvular heart lesions or atrial fibrillation. 4. Patients with injuries or wounds which hinder application of device electrodes.
• • 5. Presence of burns at site of application of electrodes.