E-cigarette Cessation in Adults Who Co-use Cannabis

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Nov 12, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at ways to help adults who use both e-cigarettes and cannabis quit using e-cigarettes. The study will use a medication called varenicline, which is approved to help people stop smoking regular cigarettes, along with financial incentives to encourage participants. The researchers want to learn how tobacco and cannabis interact when someone tries to quit using e-cigarettes. If you are between 18 and 40 years old, use e-cigarettes regularly, and have used cannabis in the past month, you may qualify to participate.

Participants in the study will receive treatment for 12 weeks and will take varenicline to help with quitting e-cigarettes. It’s important to note that you don’t need to be looking to quit cannabis to take part in this trial. The study is taking place at three locations in South Carolina, and they are currently looking for people to join. If you have any serious health issues, currently smoke regular cigarettes, or are pregnant or breastfeeding, you may not be eligible. This trial seeks to provide valuable insights into helping individuals quit e-cigarettes while considering their cannabis use.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between the ages of 18 and 40 years old
• • Use e-cigarettes daily or near daily in the past month
• • Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
• • Be interested in quitting use of e-cigarettes
• • Must be willing to take varenicline for the standard 12-week course of treatment
• • Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)
• Exclusion Criteria:
• • Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
• • Use of cigarettes on 10+ days in the past 30
• • Currently pregnant or breastfeeding
• • Current use of medications with smoking cessation efficacy
• • Use of any medications that would interfere with varenicline