Positive Expiratory Pressure (PEP) and Continuous High-frequency Oscillation (CHFO) on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study

Launched by UNIVERSITY OF GENOVA · Nov 12, 2024

Keywords

ClinConnect Summary

The PEP-RECRUIT Study is a clinical trial designed to investigate how two breathing therapies—Continuous High-Frequency Oscillation (CHFO) and Continuous Positive Expiratory Pressure (CPEP)—affect lung function in patients who are having trouble breathing and are in the intensive care unit. Researchers will use a special imaging technique called Electrical Impedance Tomography (EIT) to see how well these therapies help in expanding the lungs and clearing the airways.

To participate in this study, patients must be between the ages of 65 and 74, need help with their breathing, and have a specific level of oxygen in their blood. They also need to understand the study and agree to take part. Unfortunately, younger patients, those with serious heart issues, or those unable to use the EIT device cannot join. Participants will receive one of the therapies and be monitored to see how their lungs respond. This study aims to improve treatment options for patients experiencing respiratory failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who require pulmonary expansion and airway clearing as per clinical indication
• • Patients who provide valid informed consent according to local regulations
• • PaO2/FiO2 \< 200 mmHg at inclusion
• • Patient on the Airway Care Score (ACS) \< 7
• Exclusion Criteria:
• • Refuse to participate
• • Age \< 18 years
• • Hemodynamic instability, defined as systolic arterial pressure \< 90 mmHg or mean pressure \< 60 mmHg
• • Contraindication to using an EIT (i.e., pacemaker or defibrillator)
• • Inability to properly position the EIT device for anatomical reasons