Mts105 for Advanced Hepatocellular Carcinoma

Launched by SHEN LIN · Nov 13, 2024

Keywords

ClinConnect Summary

This clinical trial is testing a new treatment called MTS105 for patients with advanced liver cancer, specifically a type known as hepatocellular carcinoma (HCC). The main goal of this study is to see if MTS105 is safe to use and how well it is tolerated when given through an intravenous injection. The trial is currently recruiting participants who are between the ages of 18 and 74 and have been diagnosed with HCC. To be eligible, patients must have already tried at least one standard treatment, such as an immune therapy or a targeted therapy, that didn't work for them.

Participants in this trial can expect to undergo regular assessments to monitor their health and the effects of the treatment. They will need to meet specific health criteria, such as having a certain level of liver and blood function, and should not have any serious heart conditions or active infections. This trial represents an important step in exploring new options for patients whose cancer has not responded to traditional therapies, and the information gathered will help researchers understand how this new treatment might work for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Histologically or cytologically confirmed diagnosis of hepatocellular carcinoma (HCC), excluding fibrolamellar or sarcomatoid subtypes, as well as mixed hepato-cholangiocellular carcinoma;
• • 2. Positive for GPC3 expression per immunohistochemical (IHC) staining.
• • 3. Failure of standard systemic therapies, including at least one immune checkpoint inhibitor and one targeted therapy (Tyrosine Kinase Inhibitors, and/or anti vascular endothelial growth factor agent).
• • 4. Presence of a measurable tumor lesion (per RECIST/ mRECIST criteria).
• • 5. Barcelona Clinical Liver Cancer Stage B or C (BCLC B/C)
• • 6. Child-Pugh Score ≤ 6
• • 7. ECOG score ≤ 1
• 8. Adequate organ and bone marrow function as defined by the following laboratory criteria:
• • 1. Hematology: No blood transfusion or colony-stimulating factor therapy within 7 days prior to the first dose. The following hematological parameters should be met:Absolute neutrophil count ≥ 1.5 × 10\^9/L;Lymphocyte count ≥ 0.5 × 10\^9/L;Hemoglobin ≥ 90 g/L;Platelet count ≥ 75 × 10\^9/L;
• • 2. Liver function:Total bilirubin ≤ 2.5 mg/dL;Albumin ≥ 28 g/L;Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 5 × ULN;
• • 3. International Normalized Ratio (INR) ≤ 2.3;Oral anticoagulant therapy at a stable dose for at least 2 weeks. If oral warfarin is used, the patient must have an INR ≤ 3.0 and no bleeding events within 28 days prior to administration;
• • 4. Renal function:Serum creatinine ≤ 1.5 × ULN, or endogenous creatinine clearance ≥ 45 mL/min (as determined by the CKD-EPI formula);Urinary protein \< 2+, or urinary protein ≥ 2+ but with 24-hour protein quantification ≤ 1.0 g
• • 5. Cardiac function:Left ventricular ejection fraction (LVEF) ≥ 50%; No clinically significant abnormal ECG findings (chronic atrial fibrillation is allowed, provided it does not require medication);
• • 9. Capable of full communication with the investigator, with the ability to understand and comply with study requirements, and able to understand and sign the informed consent form (ICF).
• • 10. ≥18 years
• Exclusion Criteria:
• • 1. Any known active intracranial metastases, or brain metastases that have been treated for less than 4 weeks.
• 2. Recent Antitumor Therapy:
• • 1. Treatment with any immune checkpoint inhibitor within 4 weeks (28 days) prior to the first dose.
• • 2. Received any investigational drug within 4 weeks prior to the first dose.
• • 3. Received localized therapy for hepatocellular carcinoma (HCC), including but not limited to arterial chemoembolization (TACE), arterial infusion chemotherapy (HAIC), Y-90 radioembolization, ablative therapy, or stereotactic radiation therapy (SBRT), within 4 weeks prior to the first dose.
• • 4. Received other anticancer therapies, such as multi-targeted tyrosine kinase inhibitors (mTKIs) and/or anti-VEGF therapies, within 3 weeks.
• • 5. Received non-specific immunomodulatory therapy, including but not limited to interleukin, interferon, thymidine, etc., within 2 weeks prior to the first dose.
• • 6. Received herbal or proprietary Chinese medicine for antitumor indications within 1 week prior to the first dose.
• • 7. Previously received experimental treatment targeting GPC3 (patients may be enrolled if they remain positive for GPC3 upon testing).
• • 3. History of liver transplantation or hematopoietic stem cell transplantation.
• • 4. Unresolved toxicity from prior anticancer therapy (\> grade 1, according to CTCAE v5.0).
• • 5. Major surgery (other than biopsy) within 28 days prior to the first dose.
• • 6. Uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 90 mmHg).
• • 7. Class III-IV heart failure by New York Heart Association (NYHA) criteria within 6 months prior to the first dose, unstable angina, myocardial infarction, bypass surgery, stent placement, cerebral infarction, or clinically significant valvular heart disease.
• • 8. QTcF ≥ 450 ms in men and ≥ 470 ms in women (by Fridericia formula).
• • 9. Severe infection within 4 weeks before the first dose (excluding viral hepatitis), or any signs or symptoms of active infection within 2 weeks before the first dose, or patients requiring antibiotic treatment within 2 weeks (excluding local medications and prophylactic antibiotics); unexplained fever \> 38.5°C before the first dose.
• 10. For HBV-associated HCC:
• • 1. HBsAg (+) : less than 2 weeks of HBV antiviral standard treatment before the first administration of study drug, with an HBV DNA viral load ≥ 1000 IU/mL.
• • 2. HBcAb (+) , HBsAg (-): HBV DNA viral load ≥ 1000 IU/mL.
• • 11. Hepatitis C virus-infected subjects who have not completed 4 weeks of antiviral treatment.
• • 12. Positive for human immunodeficiency virus (HIV+).
• • 13. Subjects requiring systemic corticosteroids (equivalent dose of prednisone \> 10 mg/day) or other immunosuppressive drugs within 14 days prior to the first dose or during the study.
• • 14. History of autoimmune disease requiring systemic treatment within 2 years prior to the first dose.
• • 15. History of other malignancies within 2 years prior to the first dose (excluding cured skin basal cell carcinoma or squamous cell carcinoma, cervical carcinoma in situ, breast ductal carcinoma in situ, or other cancers that the investigator believes are cured and have an extremely low risk of recurrence).
• • 16. Women who are pregnant or breastfeeding.
• • 17. Any other condition that, in the opinion of the investigator, makes participation in the study inappropriate.