FAPI PET/CT to Detect Fibroblast Activity in Non-resolving ARDS
Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · Nov 13, 2024
Trial Information
Current as of July 12, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Of patients requiring mechanical ventilation in the ICU 23% meet criteria of the Acute Respiratory Distress Syndrome (ARDS). Mortality of this syndrome is high (35-46%) in moderate and severe ARDS. The fibroproliferative phase plays an important role in patients not recovering from ARDS. Bronchoalveolar lavage (BAL) can be used to investigate this process. However, quantitative assessment using BAL of fibroblast activity in both lungs is invasive, indirect and has yielded inconsistent results. This has precluded clinical utility. New methods to assess fibroblast activity in ARDS are therefo...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Mechanically ventilated
- * Patient meets the criteria for non-resolving ARDS as at day 5 of the ARDS diagnosis one or more of the following criteria is true:
- • P/F ratio \<200 mmHg
- • Positive End Expiratory Pressure (PEEP) of 12 cmH2O or more
- • Static lung compliance of \< 50 ml/cmH2O
- • Deemed safe for transport by attending clinician (staff Intensivist)
- • Informed consent signed by patient or legal representative
- • In case of COVID-19 a SARS-CoV-2 PCR CT of \> 30 is required.
- Exclusion Criteria:
- • Women who are pregnant or breastfeeding
- • Inability to attain informed consent
- • Too unstable for transport as judged by the treating staff intensivist
About University Medical Center Groningen
University Medical Center Groningen (UMCG) is a leading academic medical center in the Netherlands, renowned for its commitment to innovative research, high-quality patient care, and extensive education in the medical field. As a prominent sponsor of clinical trials, UMCG leverages its multidisciplinary expertise and state-of-the-art facilities to advance medical knowledge and improve therapeutic outcomes. The center fosters collaboration among researchers, healthcare professionals, and industry partners, aiming to translate scientific discoveries into effective treatments that enhance patient health and well-being. With a focus on ethical standards and regulatory compliance, UMCG is dedicated to conducting clinical trials that contribute to the advancement of medicine and the betterment of society.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Groningen, , Netherlands
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported