Hypofractionated Radiotherapy for Thymic Epithelial Tumors

Launched by RONGRONG ZHOU · Nov 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a type of radiation therapy called hypofractionated radiotherapy to see if it can effectively treat thymic epithelial tumors, which include thymoma and thymic carcinoma. The main aim is to find out if this treatment can shorten the overall time needed for therapy without causing more side effects compared to the standard radiation treatment. Researchers want to determine if hypofractionated radiotherapy leads to better results and fewer toxic effects for patients who have had surgery for their thymic tumors.

To participate, individuals need to be between 18 and 75 years old, have a confirmed diagnosis of thymoma or thymic carcinoma, and be in generally good health. They will receive either the new treatment or the conventional one and will need to visit the hospital for checkups every three months. It’s important for potential participants to discuss their health history with their doctor to see if they meet the eligibility requirements. This trial is currently recruiting participants, and it offers an opportunity to contribute to important research in treating thymic tumors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients must provide written informed consent.
• • 2. 18 years old ≤ age \<75 years old.
• • 3. Thymoma confirmed by pathology: type A, type AB, type B1, type B2, type B3. Thymic carcinoma. Patients with previous thymectomy were required to have complete surgical related data.
• • 4. Masaoka⁃Koga ⁃ stage Ⅰ-Ⅲ
• • 5. ECOG performance status 0-2.
• • 6. Expected survival time \> 1 year.
• • 7. Participants of childbearing age must agree to use effective contraception during the trial; In women of childbearing age, a serum or urine pregnancy test must be negative.
• • 8. Patients who are not lactating.
• • 9. Sufficient bone marrow reserve and good function of important organs.
• Exclusion Criteria:
• • 1. patients with prior thoracic radiotherapy;
• • 2. diseases not suitable for radiotherapy, such as recent myocardial infarction, active congestive heart failure;
• • 3. Uncontrolled infectious disease or other serious medical or mental illness that may interfere with care
• • 4. Patients with other malignant tumors that are not under stable control;
• • 5. Known history of mental illness, substance abuse, alcohol or drug abuse.
• • 6. Other conditions deemed unsuitable for enrollment by the attending physician.