The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients with Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DIJON · Nov 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to diagnose microvascular angina, a condition affecting the heart's small blood vessels, which can cause chest pain but is hard to detect with standard tests. Researchers want to see if measuring blood flow in the tiny vessels of the retina (the back of the eye) using a technique called Optical Coherence Tomography-Angiography (OCT-A) can provide a non-invasive way to diagnose this condition, instead of the more invasive methods currently used. The study will follow 158 participants over a year to see if there’s a link between the health of their retinal blood vessels and their heart function.

To be eligible for this trial, participants must be adults who have undergone a specific heart test called Myocardial Microcirculatory Resistance Index (IMR) and have no significant blockages in their main heart arteries. They should not have any serious eye conditions or other specific heart diseases. Those who join will have their retinal blood flow measured and will be monitored for 12 months to help researchers understand if this new method could improve how we diagnose and manage microvascular angina in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients managed at Dijon University Hospital, having had an IMR measurement as part of INOCA during a coronary angiographic examination, consecutively includible, without angiographically or functionally significant coronary epicardial lesion (FFR \< 0.80) explaining the clinical picture (= INOCA)
• • Person having given oral consent
• • Adult
• Exclusion Criteria:
• • Person not affiliated or not benefiting from a social security scheme
• • Person subject to a legal protection measure (curatorship, guardianship) or a safeguard of justice measure
• • Pregnant or breast-feeding women
• • An adult incapable or unable to give consent
• • Person with macular or retinal pathology, or severe bilateral myopia
• • Person with genetic or idiopathic cardiomyopathy (dilated, hypertrophic or restrictive cardiomyopathy)