Supplementation With Beetroot Juice to Prevent Contrast Associated Nephropathy During Hospitalization for Acute Coronary Syndrome Without ST Elevation

Launched by HOSPITAL GENERAL UNIVERSITARIO SANTA LUCIA · Nov 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether drinking beetroot juice can help prevent kidney problems that sometimes occur after certain heart procedures in patients who have been diagnosed with a type of heart condition called non-ST elevation acute coronary syndrome. These patients are at a higher risk for kidney injury because they will be receiving a special dye used during tests. The study will compare two groups: one group will drink beetroot juice along with their regular diet for seven days, while the other group will follow their usual diet without the juice. Both groups will also receive standard treatments to protect their kidneys.

To participate in this study, patients must be adults aged 65 and older, have the specified heart condition, and be at high risk for kidney problems from the dye. However, those who are pregnant, have severe health issues, or cannot eat orally will not be eligible. Participants can expect to drink two glasses of beetroot juice daily and continue their regular care while being closely monitored for any changes in kidney health. This study hopes to find out if beetroot juice can provide extra protection for the kidneys and improve heart health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of Acute Coronary Syndrome without persistent ST segment elevation, with recommendation for invasive management according to the actual Clinical practice guidelines
• • At least moderate or high risk of nephropathy associated with iodinated contrast (Mehran score (without including contrast volume) ≥ 6).
• Exclusion Criteria:
• • \<18 years old or without capacity to give consent.
• • Refusal to participate in the study.
• • Known hypersensitivity to beetroot or any of its allergens.
• • Pregnant.
• • Inability to take food orally
• • Serious illnesses (not related to ACS or kidney failure), which limits their life expectancy to a period predictably less than 1 year.
• • On dialysis or predialysis at the time of inclusion.
• • ACS with persistent ST segment elevation before inclusion.
• • Shock or inotrope dependence at the time of inclusion
• • PCI already performed before inclusion.
• • Patients receiving intravenous nitroglycerin for \> 1 hour before inclusion