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Search / Trial NCT06696027

AYLo - AutoimmunitY and Loss of y

Launched by UNIVERSITY OF BONN · Nov 15, 2024

Trial Information

Current as of July 24, 2025

Recruiting

Keywords

Autoimmune Diseases Vasculitis Large Vessel Vasculitis Giant Cell Arteritis Polymyalgia Rheumatica Anca Associated Vasculitis Idiopathic Inflammatory Myopathies Ig G4 Related Diseases Rheumatoid Arthritis Psoriatic Arthritis Connective Tissue Disease Sarcoidosis Interstitial Lung Disease

ClinConnect Summary

The AYLo study is researching how certain genetic changes, specifically the loss of the Y chromosome in blood cells, may affect autoimmune diseases, which are conditions where the body's immune system mistakenly attacks its own tissues. This trial is focusing on conditions like rheumatoid arthritis, giant cell arteritis, and asthma, among others. The goal is to understand how these genetic changes influence the way the immune system works and how they might contribute to disease progression. By gathering detailed information, the researchers hope to find new ways to tailor treatments that could improve outcomes for patients with these disorders.

To participate in this study, men over the age of 50 who have been diagnosed with specific autoimmune or inflammatory conditions may be eligible. Participants will undergo a variety of tests to help researchers learn more about the role of these genetic mutations. It's important to note that only male participants are being recruited, and those with certain other health conditions will not be included. This research aims to pave the way for personalized treatments based on individual genetic profiles, potentially leading to more effective care for those with autoimmune diseases.

Gender

MALE

Eligibility criteria

  • Inclusion Criteria:
  • Male
  • \> 50 years
  • Diagnosis of arthritis (RA, PsA), collagen diseases (SLE, systemic sclerosis, Sjögren's syndrome, mixed connective tissue diseases), vasculitis (eGPA, GPA, MPA, IgG4-related disease, GCA, PMR), sarcoidosis, COPD, ILD or asthma bronchiale confirmed by the treating physician.
  • Exclusion Criteria:
  • Female
  • \< 50 years
  • Inclusion Criteria (Healthy controls):
  • Male
  • \> 50 years
  • Exclusion Criteria (Healthy controls):
  • Female
  • \< 50 years
  • autoimmune, rheumatological diease
  • pulmonary precondition

About University Of Bonn

The University of Bonn is a renowned academic institution dedicated to advancing medical research and education. With a strong emphasis on interdisciplinary collaboration, the university engages in cutting-edge clinical trials aimed at improving patient outcomes and advancing healthcare knowledge. Its comprehensive research programs are supported by state-of-the-art facilities and a commitment to ethical standards in clinical practice. By fostering partnerships with healthcare professionals and industry leaders, the University of Bonn plays a pivotal role in translating scientific discoveries into innovative therapeutic solutions.

Locations

Bonn, Nrw, Germany

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported