The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis in Patients With Cardiac Arrest

Launched by TANG ZIREN · Nov 17, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called Median Nerve Stimulation (MNS) to see if it can help improve brain function in patients who have experienced a cardiac arrest and have regained consciousness. The goal is to find out if MNS can make a difference for patients who still show little to no purposeful movement after their heart has started beating again. In this study, about 400 participants will be randomly divided into two groups: one will receive the MNS treatment, while the other will get a placebo, which is a fake treatment that doesn’t provide any real stimulation. Both groups will undergo their assigned treatment for 8 hours each day for 14 days.

To be eligible for this trial, participants must be at least 18 years old, have stable blood flow for at least a week, and show a lack of purposeful movements after their heart has restarted following resuscitation. However, those with unstable blood flow, certain medical conditions like severe arrhythmia or a history of epilepsy, or who are pregnant, cannot participate. It's important to note that this trial is not yet recruiting participants, and the results will help determine if MNS can provide better outcomes for patients recovering from cardiac arrest.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years old.
• • 2. Hemodynamics remains continuously stable for ≥ 7 days.
• • 3. There is still a lack of purposeful movements after the return of spontaneous circulation following cardiopulmonary resuscitation.
• • 4. Advanced life support is provided within 6 hours after the return of spontaneous circulation (ROSC).
• Exclusion Criteria:
• • 1. Patients with hemodynamic instability.
• • 2. Pregnant patients.
• • 3. Those who have abnormal anatomical structures on the median nerve conduction pathway and are unable to receive electrical stimulation.
• • 4. Patients with a confirmed history of epilepsy before admission or during hospitalization.
• • 5. Patients with severe arrhythmia or those who have pacemakers implanted.
• • 6. Patients whose family members do not agree to their enrollment in the study.