NOL Index in Response to Pacemaker Stimulation

Launched by INSTITUTUL DE URGENŢĂ PENTRU BOLI CARDIOVASCULARE PROF.DR. C.C. ILIESCU · Nov 17, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to understand how heart pacing affects a special measurement called the Nociception Level Index (NOL Index), which helps assess pain levels during anesthesia. The NOL Index measures the balance between signals that indicate pain and those that help block pain. While we know how it responds to certain pain-relieving medications, researchers want to see how changes in heart rate from pacing influence this index.

If you're considering participating in this trial, you should be between the ages of 65 and 74 and have a stable heart rhythm before and after surgery. Participants need to give their consent and must not be undergoing emergency procedures or have a history of heart rhythm problems. During the trial, you can expect to be monitored closely to see how your heart pacing impacts the NOL Index. This research could help improve how we manage pain during surgeries in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed consent
• • Preoperative and postoperative sinus rhythm (50-80 bpm)
• • Norepinephrine support \< 100 ng/kg/min
• Exclusion Criteria:
• • Redo or emergent surgery
• • History of any cardiac arrhythmia
• • Any cardiocirculatory support other than norepinephrine
• • Perioperative treatment with beta-blockers, calcium-channel blockers or ivabradine