Impact of Cardiopulmonary Bypass Time on Gastrointestinal Complications

Launched by HEPATOPANCREATOBILIARY SURGERY INSTITUTE OF GANSU PROVINCE · Nov 18, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how long patients spend on a heart-lung machine, known as cardiopulmonary bypass (CPB), during heart valve replacement surgery and whether this time affects the risk of gastrointestinal complications (GICs), like problems with the stomach or intestines, after surgery. The researchers want to find out if spending more than 120 minutes on the machine increases the chances of these complications and how it impacts recovery for those who do experience them.

To participate, you must be between 18 and 75 years old and scheduled for heart valve replacement surgery that requires CPB. However, certain health conditions or recent surgeries could make you ineligible. If you join the study, you’ll be part of a group that helps us understand these important links between surgery duration and recovery, which could lead to better care for future patients. It’s important to note that the study is still recruiting participants, so there’s an opportunity to get involved if you meet the criteria.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing heart valve replacement with CPB
• • Age ≥ 18 years and ≤ 75 years
• Exclusion Criteria:
• • Have received major gastrointestinal surgery within 5 years.
• • History of severe infection (e.g., pneumonia, urinary tract infection) requiring hospitalization within 1 month prior to surgery.
• • Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis.
• • Acute gastroenteritis.
• • Clostridium difficile or Helicobacter pylori infection.
• • Chronic constipation.
• • Peptic ulcer.
• • Polyps in the stomach or intestines.
• • Gastrointestinal neoplasms.
• • Abdominal hernia.
• • Irritable bowel syndrome.
• • Acute or chronic cholecystitis, hepatitis.
• • Patients who died intraoperatively or within 24 hours postoperatively.
• • Patients with digestive system tumors.
• • Pregnancy or breastfeeding could affect postoperative medication use and study observations.
• • Involvement in other studies that may interfere with the objective results of this study.