Efficacy of Statins Among Major Depressive Disorder

Launched by AIN SHAMS UNIVERSITY · Nov 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether the medication Rosuvastatin, which is usually used to lower cholesterol, can help treat Major Depressive Disorder (MDD) in adults. Researchers want to find out if taking Rosuvastatin can reduce depression symptoms, as measured by a specific rating scale, and they will also monitor any side effects participants might experience while on the medication.

To participate in this trial, individuals should be between 20 and 45 years old and have a confirmed diagnosis of current MDD. They should also be stable on their current medications for at least two weeks before joining the study. Participants will take Rosuvastatin 10 mg daily for three months and will need to visit the clinic every four weeks for check-ups and assessments. It’s important for those interested to know that certain medical conditions and medications may exclude them from participating, so discussing eligibility with a healthcare provider is encouraged.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • aged between 20 and 45 years;
• • diagnosis of current MDD, verified using the Structured Clinical Interview for DSM-IV Axis I Disorders, patient version (SCID-I/P);
• • The Montgomery Asberg Depression Rating Scale (MADRS) score of 7 to 34, indicating mild to moderate depression;
• • the ability to give informed consent and to comply with standard procedures;
• • Males and females; and
• • Stable pharmacological treatment for at least 2 weeks prior to enrolment (changes to medication dose or frequency of therapy excepted) if currently being treated.
• Exclusion Criteria:
• • lifetime or current SCID-I/P diagnosis of a psychotic disorder;
• • lifetime SCID-I/P diagnosis of bipolar I or II disorder or alcohol dependence;
• • acute or unstable systemic medical disorder;
• • inability to comply with the requirements of informed consent or the study protocol;
• • history of intolerance or allergy to study medications;
• • Current pregnancy or breast feeding;
• • Current regular use of statins, corticosteroids, or any other immunomodulatory agents; and
• • Females on Contraception.