Risk Model for Metastasis Detection of Neuroblastoma

Launched by XINHUA HOSPITAL, SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · Nov 21, 2024

Keywords

ClinConnect Summary

1. Dataset processing. In this study, the model including training set, validation set and test sets. During the model construction, the investigators process the training in internal cohort by randomly assign the enrolled participants to the training set and validation set in a 8:2 ratio. The investigators use the enrolled participants of external cohorts as test sets to evaluate the model performance independently, and then select the best model for future use.

The Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine apaproved this study (X...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The participant newly diagnosed with NB according to the International Neuroblastoma Risk Group Staging System (INRGSS). The diagnosis completed by experienced pathologist and correlated with clinical and/or radiological findings.
• • 2. The participant diagnosed with NB at other hospitals who have not received chemotherapy or radiotherapy.
• • 3. The participant with NB has performed bone marrow smear analysis as routine examination. The bone marrow smear stained with Wright-Giemsa was made according to standard protocols.
• Exclusion Criteria:
• • 1. The participant with concurrent diagnosis of other malignancies.
• • 2. The participant with NB who has previously received chemotherapy and/or radiotherapy.
• • 3. The participant with incomplete clinical data, the metastasis state of bone marrow and/or bone is unclear.
• • 4. The participant was excluded due to non-representative specimens, such as unclear or faded Wright-Giemsa staining of bone marrow smear.