Early Screening for Gestational Diabetes Mellitus in a Low Risk Population

Launched by NATIONAL UNIVERSITY HOSPITAL, SINGAPORE · Nov 21, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the possibility of using an early screening test to detect gestational diabetes mellitus (GDM) in pregnant women who are generally considered low-risk. The study aims to find out if testing for GDM earlier in pregnancy can help prevent complications for both mothers and their babies. Researchers will also look at new ways to predict who might be at risk for developing GDM, including using a machine learning program that analyzes medical information and methods like continuous glucose monitoring, which tracks blood sugar levels over time.

To be eligible for this study, participants need to be women aged 21 to 39 who are less than 16 weeks pregnant and planning to receive care at the National University Hospital. However, women with pre-existing diabetes or those identified as high-risk for GDM based on certain health factors will not be included. If you join the trial, you can expect to participate in an early screening process that may help improve health outcomes for you and your baby. This study is currently not recruiting participants, so further details will be provided when it opens for enrollment.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Pregnant women aged 21-39 years at recruitment
• • 2. Singleton pregnancy
• • 3. Less than 16 weeks pregnant at recruitment
• • 4. Intend to receive antenatal care and give birth at the National University Hospital
• Exclusion Criteria:
• • 1. Known pre-existing type 1 or type 2 diabetes mellitus at recruitment
• 2. Classified as high-risk for GDM at pregnancy booking using the traditional checklist:
• • 2.1) Age ≥40 years 2.2) Overweight/obese, i.e., body mass index (BMI) ≥25.0 kg/m2 2.3) First degree relative with diabetes mellitus 2.4) Previously delivered a baby ≥4 kg 2.5) Previously diagnosed with GDM 2.6) Impaired glucose tolerance (IGT) or impaired fasting glycaemia (IFG) on previous testing 2.7) Polycystic ovarian syndrome (PCOS) 2.8) Poor obstetric history (e.g. recurrent pregnancy loss, previous intrauterine death, congenital malformations) 2.9) History of chronic hypertension, hyperlipidaemia or cardiovascular disease 2.10) Glycosuria ≥ 2+ on urine dipstick
• • 3. Taking systemic steroid medication or metformin
• • 4. Participation in another intervention trial