Role of Prophylactic Antiemetics in Women Receiving Intrathecal Morphine and Lipophilic Opioids Added to Bupivacaine for Cesarean Section

Launched by ASSIUT UNIVERSITY · Nov 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how to prevent nausea and vomiting after a cesarean section (C-section) for women who receive a specific type of pain relief known as intrathecal morphine. This method is commonly used for pain management after C-sections, but many women experience nausea and vomiting as a side effect, which can affect their recovery and satisfaction. The trial will specifically look at whether using a combination of two anti-nausea medications—5-HT3 antagonists and dexamethasone—can help reduce these side effects for women who receive intrathecal morphine alone or combined with another type of opioid.

To participate in this study, women must be between 19 and 40 years old, pregnant with a single baby, and scheduled for an elective C-section at least 37 weeks into their pregnancy. They should also be in stable health with normal test results. However, women with certain health conditions, allergies to the study medications, or other specified factors may not be eligible. Participants will receive the study medications and be monitored for their effects on nausea and vomiting after their surgery. This research aims to improve recovery experiences for women undergoing C-sections.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Age from 19 to 40 years old.
• • Singleton pregnancies with a gestational age of at least 37 weeks.
• • pregnant women are scheduled for elective caesarean delivery.
• • Patients with stable vital signs.
• • Patients with normal laboratory investigations.
• • patients undergoing spinal anaesthesia for caesarean delivery via Pfannenstiel incision with exteriorization of the uterus
• Exclusion Criteria:
• • • Patient's refusal.
• • Age \< 19 or \> 40 years.
• • Height\<150 cm, weight \< 60 kg, body mass index (BMI) ≥40 kg/m2.
• • Contraindications to spinal anaesthesia (Coagulopathy, increased intracranial pressure, or local skin infection).
• • Patients with cardiac morbidities.
• • hypertensive disorders of pregnancy as pre-eclampsia.
• • peripartum bleeding.
• • Patients with respiratory morbidities.
• • Convulsions.
• • Bleeding diathesis.
• • Known allergy to any drugs used in this study.