Sedation and Guided Education for Depression Study

Launched by STANFORD UNIVERSITY · Nov 21, 2024

Keywords

ClinConnect Summary

The Sedation and Guided Education for Depression Study is a clinical trial aimed at understanding how the way we educate patients about a specific treatment affects their response to that treatment. In this study, participants with major depressive disorder will receive a one-time infusion of propofol, a medication commonly used to induce sedation. Researchers want to find out if focusing on how this treatment may help (response-focused education) is more effective than simply explaining the diagnosis (diagnosis-focused education) in improving mood and well-being after the treatment.

To be eligible for this study, participants need to be adults aged 18 to 75 with moderate to severe major depressive disorder and must be able to provide written consent. Those who are pregnant, have certain substance use disorders, or specific health conditions may not qualify. Participants will receive the propofol infusion, wear a cap to monitor their brain activity, and then complete surveys about their mood and overall feelings before and after the treatment. This research is important because it could help determine the best ways to support individuals with depression during their treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of major depressive disorder of at least moderate severity
• • Able to read, understand, and provide written informed consent
• Exclusion Criteria:
• • Pregnant or breastfeeding
• • Certain substance use disorders
• • Daily use of opioids and/or benzodiazepines
• • History of psychosis, schizophrenia, or schizoaffective disorder
• • Body mass index greater than 35 kg/m2
• • Obstructive sleep apnea that is moderate and untreated, or severe
• • Any gastrointestinal condition placing the patient at significant risk of aspiration