The CACHE Study: Coronary Artery Care in HaEmophilia

Launched by OXFORD UNIVERSITY HOSPITALS NHS TRUST · Nov 22, 2024

Keywords

ClinConnect Summary

The CACHE Study is looking at heart disease in men with haemophilia, a condition that affects how well blood clots. Although people with haemophilia are less likely to die from heart disease, researchers want to understand why and how ageing might change this. They will use a special type of heart scan that creates detailed images to see how fat and plaques build up in the heart's blood vessels. By comparing these images from men with and without haemophilia, the study aims to learn more about the heart health of those with this condition.

To participate in this study, you must be a male aged 45 or older, diagnosed with haemophilia A or B, and have low levels of factor VIII or IX. Participants will need to agree to undergo scans and provide consent for the study. If you join, you can expect to have your heart health studied closely, which may help improve treatments for heart disease in people with haemophilia and even lead to better heart health strategies for everyone.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Be willing and able to give informed consent for participation in the study.
• • Male, aged 45 years or above (no upper age limit).
• • Haemophilia A or B with Factor VIII/IX less than 40% (0.40 IU/ml).
• Exclusion Criteria:
• • Participants unable or unwilling to give informed consent.
• • Participants unable to understand the English language.
• • Participants unable or unwilling to attend for the necessary scans and investigations.
• * Patients with absolute contra-indications to CT imaging will be excluded from the study. This includes:
• • Any known contraindications to CT iodinated Contrast.
• • Significant renal impairment (eGFR \<30 ml/min).
• • Any other medical conditions which would influence the reliability of the study results determined by the investigators.