Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)

Launched by NANJING MEDICAL UNIVERSITY · Nov 24, 2024

Keywords

ClinConnect Summary

The clinical trial titled "Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery" aims to explore a technique called remote ischaemic pre-conditioning (RIPC). This method involves briefly restricting blood flow to an arm or leg to potentially protect the heart and other organs during cardiovascular surgery. Researchers want to find out if this approach can reduce inflammation and prevent complications after surgery, particularly in patients who are at high risk for organ problems.

To be eligible for this trial, participants should be between 18 and 80 years old and are scheduled for elective heart surgery that requires a procedure called cardiopulmonary bypass. They must also be willing to give their consent to join the study. However, individuals with certain conditions, such as arm injuries, nerve damage, or poor blood flow to the limbs, won't be able to participate. If you join the trial, you can expect to receive RIPC treatment as part of your surgery preparation, and the research team will monitor your recovery closely to see how well this method works.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients at high risk for organ dysfunctions who underwent elective cardiovascular surgery requiring cardiopulmonary bypass (CPB);
• • age of 18 -80 years old, regardless of gender;
• • subjects voluntarily participate in the trialand sign the informed consent;
• Exclusion Criteria:
• • 1) Arm fracture, skin injury or infection;
• • 2) There is limb nerve injury;
• • 3) Limb placement PICC, arteriovenous fistula and other devices that affect armband placement;
• • 4) There are basic vascular lesions and poor blood supply at the extremities;
• • 5) Limb thrombosis.