Washed Microbiota Transplantation in Solid Organ Transplantation

Launched by THE SECOND HOSPITAL OF NANJING MEDICAL UNIVERSITY · Nov 24, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment called washed microbiota transplantation (WMT) to help patients who have received solid organ transplants, like kidneys or livers, and are experiencing complications such as gastrointestinal issues, infections, or graft rejection. These complications can be serious and affect the success of the transplant and the patient's overall health. The researchers believe that restoring the balance of healthy bacteria in the gut may improve these issues, as many transplant patients often struggle with gut health due to medications and other factors.

To be eligible for this trial, participants must be recipients of a solid organ transplant and experiencing specific problems like diarrhea, infections, or signs of graft rejection. They also need to be willing to undergo the WMT procedure and provide consent. The trial is not yet recruiting, meaning it hasn't started accepting participants yet. If you or a loved one qualifies, you can expect to receive the new treatment and be closely monitored by the study team to assess how well it works and if it is safe. It's an exciting opportunity that could potentially lead to better care for those facing complications after a transplant.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. solid organ transplantation recipients;
• • 2. suffering from gastrointestinal symptoms (e.g. diarrhea, constipation, abdominal pian), infection (e.g. Clostridium difficile, urinary infection) post-transplantation, graft rejection and so on;
• • 3. is willing to undergo WMT and provide written informed consent;
• Exclusion Criteria:
• • 1. patients with history of gastrointestinal diseases or homologous pathogen infection pre-transplant;
• • 2. pregnant or lactating females;
• • 3. unable to understand the purpose of the study, communicate effectively with investigators and comply with all study procedures;
• • 4. follow up less than 1-month post-WMT;
• • 5. other conditions judged by investigators not suitable for study participation;