Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

Launched by RIGSHOSPITALET, DENMARK · Nov 27, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating whether using antibiotics specifically chosen based on the bacteria found in urine can help prevent infections after bladder removal surgery, known as cystectomy. Participants in the study will be randomly assigned to one of two groups: one group will receive a standard antibiotic that is usually given after surgery, while the other group will receive antibiotics that are tailored to the bacteria identified in their urine. Researchers hope that the targeted approach will lead to fewer patients needing to return to the hospital for infections within 90 days after their surgery.

To participate in this trial, individuals must be at least 18 years old and able to understand and sign consent forms. They should be having surgery for bladder cancer or other reasons that require cystectomy and will have an ileal conduit, which is a way to divert urine after the bladder is removed. Participants should be aware that those with a history of severe allergic reactions to antibiotics or who are on long-term antibiotic treatment may not be eligible for this study. Overall, this trial aims to improve post-surgical care and reduce the risk of infections for patients undergoing this significant procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age at surgery ≥ 18 years
• • Ability to understand and sign an informed consent
• • Malignant or benign indication for undergoing cystectomy
• • Planned ileal conduit as urinary diversion
• Exclusion Criteria:
• • Previous severe allergic reaction to antimicrobial treatment
• • Long-term prophylactic antibiotic treatment which is expected to be continued after the cystectomy