AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis

Launched by UNIVERSITY COLLEGE CORK · Nov 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to assess disease activity in patients with Ulcerative Colitis (UC) using advanced imaging techniques. The goal is to create a simple scoring system that can help doctors better understand whether a patient's disease is currently inactive or showing mild inflammation. By comparing this new score to existing methods, the researchers hope to improve how UC is diagnosed and predict long-term outcomes for patients.

To participate in this trial, you must be an adult between 18 and 75 years old with a confirmed diagnosis of Ulcerative Colitis that has lasted at least six months. You should also be scheduled for an endoscopy, a procedure that allows doctors to look at your colon. However, certain conditions may prevent you from joining, such as serious health issues or if you have recently participated in another experimental trial. If you are eligible and decide to join, you can expect to undergo an endoscopy where this new scoring system will be tested to help improve UC care in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients aged 18 to 75 years old
• • Established diagnosis of UC (for at least six months in duration), independently from their active treatment
• • Undergoing endoscopy for disease activity assessment or cancer surveillance.
• Exclusion Criteria:
• • Contraindications to endoscopy (including toxic megacolon) and biopsies (including severe coagulopathy/thrombocytopenia)
• • Poor bowel preparation (defined as total BBPS \<6 or BBPS \<2 in observed segment for sigmoidoscopy)
• • Significant co-morbidities limiting life expectancy and conferring high risk of endoscopy
• • Pregnant and breast-feeding subjects
• • Inability to provide informed consent
• • If the participant has been in a recent experimental trial, these must have been completed not less than thirty days prior to this study