A Study of LY4060874 in Healthy Participants

Launched by ELI LILLY AND COMPANY · Nov 26, 2024

Keywords

ClinConnect Summary

This clinical trial is testing a new medication called LY4060874 to see how safe it is and how well people can tolerate it. The study is open to healthy participants aged between 18 and 65, and it will last up to 22 weeks, including about 16 visits to the study site. To be eligible, participants must be in good health as determined by a medical check-up, have a specific body weight range, and meet certain ancestry criteria related to Chinese or Japanese descent.

Participants in this study should not have a history of diabetes or be on any weight loss medications. During the trial, they can expect regular health evaluations, and their overall well-being will be closely monitored. This is a great opportunity for individuals who meet the criteria and are interested in contributing to medical research while helping to advance our understanding of this new medication.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Are overtly healthy as determined by medical evaluation, including medical history and physical examination.
• • Have a body mass index in the range of 20 to 29.9 kilogram per meter squared (kg/m²), inclusive, at screening.
• • To qualify as Chinese for this study, all 4 of the participant's biological grandparents must be of exclusive Chinese descent and born in China.
• • To qualify as a participant of first-generation Japanese origin, the participant, the participant's biological parents, and all the participants' biological grandparents must be of exclusive Japanese descent and born in Japan.
• Exclusion Criteria:
• • Have a history of or have been diagnosed with Type 1 or Type 2 diabetes mellitus.
• • Have hemoglobin A1c (HbA1c) \> 6.4% or 46 millimoles/mole (mmol/mol) at screening.
• • Have taken approved, including over the counter (OTC) or prescribed, medication or investigational medication for weight loss, including GLP-1 receptor agonists, within the previous 3 months of study screening.
• • Have had surgical treatment for obesity.
• • Are actively participating in a weight loss program or intend to initiate an intensive diet and/or exercise program during the study.