Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage

Launched by BEIJING TIANTAN HOSPITAL · Nov 28, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment approach called Remote Ischemic Conditioning (RIC) for patients who have experienced an aneurysmal subarachnoid hemorrhage (SAH), which is bleeding in the space around the brain. Previous studies have not been successful in improving outcomes for SAH patients, so researchers are looking for innovative methods to help these individuals recover better. RIC is a technique that may help protect brain function and improve recovery, but it is still being studied to understand how it works and how effective it might be.

To be eligible for this trial, participants must be between 18 and 80 years old and have been diagnosed with an aneurysmal subarachnoid hemorrhage within 72 hours of the event. They should also have a specific grade of severity when they arrive at the hospital and have undergone a certain type of treatment for their aneurysm. If someone joins the trial, they will receive RIC treatment, and the researchers will monitor their progress to see if it leads to better outcomes compared to standard care. This study is not yet recruiting participants, but it represents an important step towards finding new ways to support recovery after SAH.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with aneurysmal subarachnoid hemorrhage confirmed by imaging examination (diagnosed by computed tomography and confirmation of an intracranial aneurysm by CT angiography or digital subtraction angiography);
• • 2. The Hunt-Hess grade is 2-3 at admission;
• • 3. Onset of aneurysmal subarachnoid hemorrhage ≤72 hours;
• • 4. The responsible aneurysm has been treated by endovascular interventional therapy;
• • 5. 18≤ age ≤80 years old;
• • 6. Informed consent must be obtained from participants or legally authorized representatives.
• Exclusion Criteria:
• • 1. Patients with other intracerebral hemorrhage or other types of subarachnoid hemorrhage;
• • 2. Previous neurological deficits (mRS Score ≥1) or psychiatric disorders that can confound neurological or functional assessments;
• • 3. With severe comorbidities and a life expectancy of less than 90 days;
• • 4. Refractory hypertension (Systolic blood pressure\> 180 mmHg or diastolic blood pressure \>110 mmHg);
• • 5. Contraindications of RIC: severe soft tissue injury of the lower limbs, etc;
• • 6. Concurrent participation in another protocol investigating a different experimental therapy;
• • 7. Any condition that the investigator believes may increase the patient's risk.