Biomarkers in EV Associated With Marrow Adiposity in Anorexia
Launched by MAIMÓNIDES BIOMEDICAL RESEARCH INSTITUTE OF CÓRDOBA · Nov 26, 2024
Trial Information
Current as of July 12, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking to understand more about anorexia nervosa, specifically how fat in the bone marrow might be linked to bone health issues in patients with this condition. Researchers want to find out if certain markers found in tiny particles called extracellular vesicles can help explain the bone problems often seen in people with anorexia. The study will involve measuring the body composition of participants and taking a simple blood sample without any invasive procedures.
To participate, individuals must be diagnosed with anorexia nervosa or have recently recovered from it, meaning they have gained some weight and are menstruating normally. The study is open to people of all genders, but they must meet specific health criteria, such as having a low body mass index (BMI) if they are currently struggling with anorexia. Participants will not be allowed to be on certain medications or have chronic diseases that could affect the results. The trial is not recruiting yet, but it aims to provide valuable insights into how anorexia impacts bone health.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- For AN group:
- • Diagnosis of active AN according to DSM-5 criteria
- • BMI of less than 17kg/m2
- • Present amenorrhoea in the 3 months prior to the start of the study.
- For AN-R group:
- • Achieved weight gain of more than 85%.
- • Normal menstruation in the last 3 months.
- For Control group:
- • Population of the same age and gender as the AN and AN-R groups.
- • If pubertal population, presenting a chronological age of ± 2 years.
- • Normal menstruation
- • Normal BMI (\>18.5 kg/m2)
- • No presence of previous dietary transtrons.
- Exclusion Criteria:
- • Not receiving oestrogens, contraceptives or glucocorticoids in the 3 months prior to the start of the study.
- • Not to suffer from chronic diseases, such as diabetes, pathologies affecting the bone system or thyroid function.
- • Do not take calcium or vitamin supplements.
About Maimónides Biomedical Research Institute Of Córdoba
The Maimónides Biomedical Research Institute of Córdoba is a leading research organization dedicated to advancing biomedical science through innovative clinical trials and translational research. Located in Córdoba, Spain, the institute focuses on a multidisciplinary approach to address pressing health challenges, fostering collaboration among researchers, clinicians, and industry partners. Its commitment to excellence in research is complemented by state-of-the-art facilities and a robust ethical framework, ensuring the highest standards of scientific integrity and patient safety. By prioritizing cutting-edge research and the development of novel therapeutic strategies, the Maimónides Biomedical Research Institute aims to contribute significantly to the improvement of global health outcomes.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Córdoba, , Spain
Patients applied
Trial Officials
Marta Camacho-Cardenosa, pHd
Principal Investigator
Maimonides Biomedical Research Institute of Córdoba
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported