Interleukin 8 And10 Levels Changes in Teeth with Necrotic Pulp and Apical Periodontitis

Launched by FACULTY OF DENTAL MEDICINE FOR GIRLS · Dec 2, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain substances in the body, called interleukin 8 (IL-8) and interleukin 10 (IL-10), change during root canal treatment for patients with a specific dental issue known as pulp necrosis and apical periodontitis. Essentially, the researchers want to understand how the levels of these substances in the fluid around the teeth vary before and after treatment, which could help improve care for patients with these conditions.

To be part of this study, participants need to be adults aged 18 to 45 who are generally healthy and have a specific type of tooth issue that hasn’t been treated before. If someone joins the study, they will provide small samples of fluid from their gums and around the affected tooth at two different times during their root canal treatment. This trial is not yet recruiting participants, but it aims to ensure that the treatment is effective and safe by monitoring these key substances in the body.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:Inclusion Criteria:
• • 1. Adult patients aged between 18 and 45 years.
• • 2. Patients without any systemic diseases.
• • 3. Patients diagnosed with pulp necrosis and apical periodontitis of a single root with a single canal who are seeking endodontic treatment.
• • 4. Patients who have not previously received endodontic treatment or any related therapeutic procedures.
• • 5. Patients with normal periodontal health.
• Inclusion Criteria:
• • 1. Adult patients aged between 18 and 45 years. 2. Patients without any systemic diseases. 3. Patients diagnosed with pulp necrosis and apical periodontitis of a single root with a single canal who are seeking endodontic treatment. 4. Patients who have not previously received endodontic treatment or any related therapeutic procedures. 5. Patients with normal periodontal health.
• • -
• Exclusion Criteria:
• * Exclusion Criteria:
• • 1. Patients who refuse to participate in the study.
• • 2. Patients who have been on long-term anti-inflammatory medication,received immunosuppressive chemotherapy or taken antibiotics within the last 3 weeks.
• • 3. Patients with systemic health conditions such as cardiovascular and respiratory diseases, diabetes mellitus, HIV infection, or hepatitis.
• • 4. Unrestorable teeth, pregnant women, and smokers will also be excluded from the study