Intravenous Versus Oral Treatment of the Main Acute Infections

Launched by UNIVERSITY OF SOUTHERN DENMARK · Dec 3, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of oral antibiotics compared to intravenous (IV) antibiotics for treating common acute infections, such as respiratory tract infections, urinary tract infections, and cellulitis. Many patients with these infections are currently treated in the hospital with IV antibiotics, but the researchers want to see if oral antibiotics could be just as effective and safe. This change could help reduce hospital stays and costs since some patients may not need to be hospitalized just for IV treatment.

To participate in this study, you need to be 65 years or older and have a suspected infection that requires antibiotics. You must also have been planned to receive IV antibiotics. However, if you’ve already received more than two doses of IV antibiotics, are experiencing certain health issues (like very low blood pressure or severe nausea), or are pregnant, you may not be eligible. If you take part, you can expect to receive either oral or IV antibiotics and will be closely monitored for how well the treatment works and if there are any safety concerns. This trial is important because it could lead to changes in how these infections are treated, making it easier for patients to recover at home rather than in the hospital.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Suspected respiratory tract infection, urinary tract infection, or cellulitis by the attending physician
• • Planned or initiated intravenous antibiotic treatment
• Exclusion Criteria:
• • if received more than two doses of intravenous antibiotics;
• • systolic blood pressure \<90 mmHg;
• • nausea and/or vomiting in more than one short-term instance during the last 2 days;
• • suspected significantly reduced gastrointestinal absorption;
• • confirmed plasma-lactate \> 2;
• • pregnant or nursing;
• • unable to give informed consent;
• • severe immunodeficiency;
• • urgent vital treatment needed.