Effect of Propofol Administration Time on the Incidence and Severity of Intrathecal Morphine-induced Pruritus in Parturient Undergoing Elective Cesarean Delivaries

Launched by ASSIUT UNIVERSITY · Dec 3, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the timing of a medication called propofol affects itching that can occur after receiving morphine during an elective cesarean section (C-section). The researchers want to find out if giving propofol before or after the morphine injection changes how often patients experience itching and how severe it is. This study will help doctors understand better ways to manage this uncomfortable side effect for women undergoing C-sections.

To be eligible for the trial, participants must be women aged 20 to 40 years, in good health (specifically, classified as ASA class I or II), and at least 37 weeks pregnant with a single baby. They must also be scheduled for an elective C-section using a specific type of anesthesia called intrathecal anesthesia. However, women with certain health issues, allergies to the medications being tested, or those who require an emergency C-section will not be able to participate. If you join the study, you can expect to receive either propofol before or after your morphine, and researchers will monitor your experience to gather important information to improve care for future patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Parturient of American Society of Anaesthesiologists (ASA) class I or II physical status.
• • Age: 20-40 years.
• • At term gestation (≥ 37 weeks) with a singleton uncomplicated pregnancy.
• • Elective cesarean delivery under intrathecal anaesthesia
• Exclusion Criteria:
• • Parturient refusal.
• • Significant organ dysfunctions (e.g., cardiac, respiratory, renal, or liver disorders).
• • Morbid obesity (BMI \>35).
• • Parturient with known hypersensitivity to propofol, morphine or amide local anaesthetics.
• • Parturient with pruritogenic systemic disease.
• • A coexisting skin disorder or preexisting pregnancy induced pruritus.
• • Parturient with any contraindication for intrathecal anaesthesia, e.g. coagulopathy.
• • Emergency cesarean section.
• • Failed or unsatisfactory intrathecal block.