How Many Dexamethasone Doses Should Be Given Perioperatively?

Launched by MAYO CLINIC · Nov 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different doses of a medication called dexamethasone can help patients during and after total knee replacement surgery (also known as total knee arthroplasty). The goal is to find out which dose is the most effective and safest for reducing pain, nausea, and the need for additional pain medication after the surgery, while also minimizing any complications that might arise.

To participate in this study, you need to be over 18 years old and scheduled for a primary total knee replacement surgery. Unfortunately, if you have certain conditions like recent corticosteroid use, inflammatory arthritis, or kidney and liver problems, you wouldn't be eligible to join. If you do participate, you can expect to receive a specific dose of dexamethasone around the time of your surgery, and your doctors will monitor your recovery closely to gather important information about how well the medication works. This study is currently recruiting participants, and it's open to anyone who meets the criteria, regardless of gender.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Age \> 18 years
• • Primary total knee arthroplasty
• • Exclusion Criteria
• • Age \< 18 year
• • Revision or unicompartmental knee arthroplasty
• • Corticosteroid use within 3 months prior to TKA
• • Inflammatory arthritis
• • Current systemic fungal infection
• • Renal or liver failure
• • Prior adverse reaction to corticosteroid
• • Primary TKA requiring hardware removal