Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical Network Dynamics in Dystonic Patients with Deep Brain Stimulation
Launched by FONDAZIONE I.R.C.C.S. ISTITUTO NEUROLOGICO CARLO BESTA · Dec 2, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The DYScover trial is a study aimed at better understanding dystonia, a movement disorder that causes involuntary muscle contractions. Specifically, researchers want to learn how deep brain stimulation (DBS) affects certain brain networks over time in patients who have already undergone this treatment. Participants will include individuals aged 12 and older who have been diagnosed with either idiopathic or genetic dystonia and have had DBS surgery in a specific part of the brain called the globus pallidus internus. These individuals must also have a special neurostimulator that can record brain activity.
During the trial, participants can expect to undergo regular clinical evaluations, as well as advanced brain imaging tests like magnetoencephalography (MEG) and functional MRI (fMRI). The goal is to see if changes in brain activity are linked to improvements in their symptoms. This research may help doctors better understand the underlying issues of dystonia and could pave the way for more effective treatments in the future, including a more advanced form of DBS that adapts based on brain activity.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients diagnosed with idiopathic or genetic dystonia who have already undergone DBS surgery of the globus pallidus internus
- • Patient implanted with a neurostimulator capable of chronically recording LFPs and which is fully compatible with magnetic fields up to 3 Tesla.
- • Age\>12 years
- Exclusion Criteria:
- • Evidence of CNS pathology or any other acquired conditions (perinatal, infective, toxic, neoplastic, vascular, psychogenic) responsible for the dystonia phenomenology,
- • Focal distribution of dystonia
- • Contraindications to brain MRI or EEG/MEG
- • Adult subjects unable to express consent to inclusion in the study
- • Pregnancy, and breastfeeding.
About Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta is a prestigious research institute in Italy dedicated to advancing the field of neurology through innovative clinical trials and translational research. As a leading center of excellence, it focuses on the diagnosis and treatment of neurological disorders, fostering collaboration among clinicians, researchers, and healthcare professionals. The foundation is committed to improving patient outcomes by integrating cutting-edge scientific research with clinical practice, ensuring that groundbreaking therapies and interventions are effectively translated into real-world applications for individuals affected by neurological conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Milano, , Italy
Patients applied
Trial Officials
Vincenzo Levi, MD
Principal Investigator
Fondazione IRCCS Istituto Neurologico Carlo Besta
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported