Description of the Immune Response to Yellow Fever Vaccination

Launched by INSTITUT PASTEUR · Dec 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how our immune system responds to the yellow fever vaccine. Researchers want to understand not just the specific protection it offers against yellow fever, but also if it can help our body fight off other infections as well. This concept is called "trained immunity," which means that the immune system can be prepared to defend against various threats after being exposed to certain vaccines.

To participate in this study, you need to be between the ages of 18 and 65 and have been referred for yellow fever and typhoid vaccinations. You should be able to attend two appointments scheduled seven days apart, and your health should allow for a small blood sample to be taken. However, if you have had these vaccinations before, lived in an area where these diseases are common, or are pregnant or breastfeeding, you may not be eligible. If you join the study, you'll help researchers learn more about how vaccines can boost our immune defenses, and in return, you'll receive the vaccinations as part of your routine care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 18 and 65
• • Referred for immunisation against yellow fever and typhoid
• * Any person with indication for the following vaccinations :
• • Yellow fever
• • Typhoïd
• • Whose vaccination schedule includes two appointments 7 days apart
• • Whose state of health is compatible with a single 51 ml blood sample collection
• • Have consented to participate in the Ivory2 study
• • Benefiting from a Social Security plan or equivalent
• Exclusion Criteria:
• • Anyone with a contraindication to yellow fever and/or typhoid vaccination.
• • Any person who has been vaccinated against yellow fever and/or typhoid.
• • Anyone who has lived in an endemic area (≥ 1 year) and/or has a history of Typhoid.
• • Anyone who is unable to attend the visit 1-month after the typhoid vaccine injection.
• • Women claiming to be pregnant or breast-feeding
• • Anyone unable to give informed consent for participation